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While the effects of smoking, age, and chronic respiratory diseases on mucociliary function are well established [75, 76], mechanisms in acute illness are less well studied

3), and the backbone of each complex also closely resembled the previously determined active structures of individual AMYRs bound to rat Amy (rAmy) 15 (Fig

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Our findings not only establish an efficient nanopore-based platform for discovering protein oligomerization inducers but also introduce CaPPO as a design paradigm for targeting WDR5 and other therapeutically relevant proteins

Indeed, Zfp423 and Zfp521 both play important roles in neural development

[DOI] [PubMed] [Google Scholar] Xia Y., Li Q., Zhong W., Dong J., Wang Z., Wang C