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Due to the mediating position of the folate cycle between the two adjacent cycles, a folic acid deficiency has widespread consequences: the production of SAM falls, as does that of BH4 and the associated neurotransmitters

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Retrieved May 27, 2025, from National Institutes of Health

REVIEW DOCUMENTATION Chart documentation should be evaluated to confirm that all necessary requirements are completed per insurance payer guidelines

Such measures remove the need for long-term administration of cyanocobalamin