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Also known as AS Anterior Segment -SMA -smooth muscle actin Bcl-2 B-cel lymphoma 2 apoptosis regulator protein BSTP British Society of Toxicological Pathologists CD (31, 34, 68) Cluster differentiation (31, 34, 68) CEA Carcinoembryonic antigen CK Cytokeratin ED1 Rat homologue of human CD68 EM Electron microscopy ESTP European Society of Toxicologic Pathology Factor VIII Blood clotting factor/anti-hemophilic factor F4/80 Rat anti-mouse macrophage monoclonal antibody H&E Hematoxylin and Eosin IHC Immunohistochemistry JSTP The Japanese Society of Toxicologic Pathology Ki-67 Nuclear protein associated with proliferation LAMP Lysosome-associated protein LLL Lef lateral lobe LML Left medial lobe MIB-1 Monoclonal antibody that detects K-67 antigen on formalin fixed paraffin embedded sections MS Middle Segment NTP National Toxicology Program NLDC-145 Rat anti-mouse dendritic cell monoclonal antibody NOS Not otherwise specified OX-6 MHC Class II Ia antibody PAS Periodic acid-Schiff PC Caudate Process PCNA Proliferator Cell Nuclear Antigen PCR Polymerase Chain Reaction PP Papillary Process PPA Processus papillaris anterior PPAR Peroxisome Proliferator-Activated Receptor PS Posterior Segment RER Rough Endoplasmic Reticulum RLL Right lateral lobe RML Right medial lobe SRA-E5 Mouse monoclonal anti-macrophage antibody for Scavenger Receptor A SOPs Standard Operating Procedures STP Society of Toxicologic Pathology

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These effects are largely indirect, stemming from the compounds ability to inhibit nicotinamide N-methyltransferase (NNMT) , a regulatory enzyme that consumes nicotinamide and depletes methyl donor pools (Kraus D, 2014)