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Generally, this is due to the body spending fewer hours in deep sleep and producing less melatonin the hormone responsible for eliciting sleepiness

Clarke JR, Lyra E, Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazo R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG (2015) Alzheimer-associated A oligomers impact the central nervous system to induce peripheral metabolic deregulation

The values are presented in kcal/mol