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112,113 A single dose of CTX310 in non-human primates resulted in 70% mean editing of ANGPTL3 in the liver, an over 85% reduction in plasma ANGPTL3 protein, and a 60% reduction in TG, with effects lasting beyond a year and only transient liver enzyme elevation

These enzymes play role in different pathways [33] and in RNA modification

The normal morphology and arrangement of adipocytes are associated with a lower risk of metabolic syndrome and can prevent chronic disorders such as cardiovascular disease and diabetes (23)

The availability of carnitine in muscle plays a central role in regulating muscle fuel metabolism [266, 267]
Non-alcoholic fatty liver disease development: A multifactorial pathogenic phenomena
