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J Clin Oncol 20 : 19231931 Estlin EJ, Pinkerton CR, Lewis IJ, Lashford L, McDowell H, Morland B, Kohler J, Newell DR, Boddy AV, Taylor GA, Price L, Ablett S, Hobson R, Pitsiladis M, Brampton M, Clendeninn N, Johnston A, Pearson AD (2001) A phase I study of nolatrexed dihydrochloride in children with advanced cancer

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Recent studies in humans, dogs, and cats suggest that oral supplementation is as equally effective as parenteral supplementation

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The technique differs from intramuscular injection, which uses longer needles and deeper penetration

Comprehensive preclinical safety evaluations across multiple animal models demonstrate favorable tolerability profiles with excellent safety margins for investigational research applications