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The kinase identified as Aurora B kinase (encoded by the AURKB gene) has previously been shown to be a major contributor to the phosphorylation of Ser 10 in histone H3

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Oxidative biotransformation of S-Me-DDC forms S-diethylthiomethylcarbamate (S-Me-DTC), which could be further oxidized to S-Me-DTC-sulphoxide and S-Me-DTC-sulphone metabolites, respectively ( Pharmacodynamics of Disulfiram Ethanol metabolism in the liver predominantly relies on the action of ALDH isozymes and a minor amount of ethanol is metabolised through P450 mono-oxygenases and catalases

10.1007/s00134-016-4475-4 53 LeeJ.BanerjeeD

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Actually, in this establishment of model, hepatocytes are sandwiched between two layers of artificial matrix glues, rebuilding the polarity of cells and forming a complete bile duct network in order to mimic the internal environment of hepatocytes realistically (Matsunaga et al., 2016)