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Human evidence is increasingly becoming diverse: biomarker and PK/PD studies (such as sulforaphane preparations that stimulate NRF2 and ARE gene expression in blood cells or target tissues) are the most persuasive human evidence, and only a few randomized trials and pilot studies indicate the ability to modulate oxidative-stress or inflammatory markers [271]
[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Liu P., Feng Y., Li H., Chen X., Wang G., Xu S., Li Y., Zhao L

Bull World Health Organ 59:391395 [PMC free article] [PubMed] [Google Scholar] Davidson RG, Nitowsky HM, Childs B (1963) Demonstration of two populations of cells in the human female heterozygous for glucose-6-phosphate dehydrogenase variants

2019 Jan 8;29(1):141-155.e9
[DOI] [PMC free article] [PubMed] [Google Scholar] 318.Alhowyan A.A., Kalam M.A., Iqbal M., Raish M., El-Toni A.M., Alkholief M., Almomen A.A., Alshamsan A

The benzyl alcohol preservative is generally safe at the tiny doses used for diluting medications in adults, but it poses severe risk to neonates
