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Those with a history of cancer or with a metabolic or endocrine disorder also need to proceed with care

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Antioxidants 11(6):1157 Lee HY, Byeon Y, Lee K, Lee HJ, Back K (2014) Cloning of Arabidopsis serotonin N-acetyltransferase and its role with caffeic acid O-methyltransferase in the biosynthesis of melatonin in vitro despite their different subcellular localizations

However, studies on CAF supplementation have shown substantial variability in outcomes, with some studies reporting no benefits or even a worsening of performance in certain subjects