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Correlation between AGEs and feature of PCOS PCOS has been defined as a disorder due to an excess of androgens and insulin resistance, about 5070% of women with PCOS have a certain degree of resistance to insulin, which is defined as a state in which more insulin is required than the normal to obtain an appropriate response [47]

Hara et al reported two LBD mutations, W741L and W741C, in LNCaP cells that appeared during bicalutamide treatment and caused the receptor to be activated by bicalutamide 172

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