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The role of ABCC1 in resistance to the studied thiosemicarbazones was further evaluated using parental HEK-293 cells and their ABCC1-transfected derivative, HEK-293-C1

Mechanistically, phosphorylation of JNK, cJun and p65 (NFB) peaked within 60 min (Fig

Notably, analogous effects have not been consistently demonstrated in males, underscoring the sex-specific nature of neuroendocrine adaptations ( Lactation represents a period of exceptionally high metabolic demand during the mammalian life cycle

doi: 10.1038/srep34827 74 SainiVFarhanaASteynAJ