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456 Chronic lymphocytic leukemia (CLL) patients with high proliferation features have upregulated OXPHOS and the mTOR pathway

The relative importance of the glutathione system compared to the more important thioredoxin system may be further amplified under acute oxidative challenge as thioredoxins or thioredoxin reductases may readily become limiting and/or oxidised and thus inactive [62], which would strongly limit the capacity of the thioredoxin pathway to act as a conduit of anti-oxidative electron flux

Romshe et al., 1984)

RuMP Pathway The RuMP pathway comprises two enzymes, 3-hexulose-6-phosphate synthase (Hps, EC 4.1.2.43) and 6-phospho-3-hexuloisomerase (Phi, EC 5.3.1.27) [ Figure 2B

doi:10.1016/j.ab.2009.04.009

The method is based on the reduction of Fe 3+ - TPTZ (2,4,6-tripyridyl-s-triazine) complex (FRAP reagent) to the ferrous (Fe 2+ ) form