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M.BongarzoneE
They should never be frozen

Although in most cases the disease can be resolved on its own, in severe cases patients may not resist the diffuse and massive alveolar damage associated with disease progression and, ultimately, pass away

Neurosci Bull 39(1):113124 Dionsio PA, Amaral JD, Rodrigues CMP (2021) Oxidative stress and regulated cell death in Parkinsons disease

Hence, the intracellular redox state, which is characterized by the levels and ratios of oxidized (GSSG) and reduced (GSH) glutathione, is regarded as a significant indication of the cellular health (Lu 2013)

Concurrently, they stimulate the production of transforming growth factor-beta 1 (TGF-1) and the C-terminal propeptide of type I collagen (CICP)biomarkers indicative of active collagen synthesisthereby facilitating extracellular matrix deposition, maturation, and dynamic tissue remodeling during wound healing
