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Despite the variety of mechanisms through which current drugs operate, most approved treatments fail to prevent the pathological progression of AD, and often exhibit limited efficacy or notable side effects (12,13)

Conclusion and Future Perspectives Abiotic stresses including the heavy metal stress profusely arrests crop yield and productivity

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Endolysosomal zinc dysregulation Defects in the endosomeautophagosomelysosome pathway, the major machinery for degrading protein aggregates and damaged organelles, are central drivers of neurodegenerative diseases such as Alzheimers disease, Parkinsons disease and ALS 166

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