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investigated the cytotoxic effects of copper and its underlying molecular mechanisms, revealing that copper (II) enhances the expression of Bax and ROS, subsequently inactivating NFB and inducing apoptosis in the murine pre-B cell line BA/F3b

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The effects of RPM on the transcriptome profile during follicular and early embryo were investigated, and the results showed that it is likely that DNA methylation may have been a mechanism utilized to modulate gene expression patterns (Peagaricano et al., 2013)

Funding This work was supported by Priority Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University (No.202201 AY070001 - 066), Funding of the"famous doctors"project of the support plan for the talents of Xingdian (No.RLMY20220005), The scientific and technological innovation team of Kunming Medical University (CXTD202209), Yunnan Provincial Endocrinology and Metabolism Clinical Medicine Center (YWLCYXZXXYS20221005),Clinical Collaboration Project of Traditional Chinese and Western Medicine for Major Difficult Diseases of Yunnan Province (300073)

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Kisspeptin research indicates it may serve as a diagnostic probe to assay HPG axis responsiveness prior to selecting targeted treatments