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Watch for microalbuminuria, small GFR shifts, and subtle inflammatory signals, rather than waiting for severe thresholds that may be irreversible

MIF binding to CD74 on MDSCs has been shown to activate various cell signaling pathways, including the PI3K/AKT and MAPK pathways, which are associated with immunosuppressive functions [135]

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Furthermore, genetic polymorphism in GSTs is pressumed to influence metabolism and disposition of various anticancerogenic drugs (Crettol et al., 2010)