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Additionally, several key clinical trial readouts delivered compelling data across multiple indications, for example (see Figure 1): Semaglutide : STEP-HFpEF (functional benefits in HFpEF), STEP-9 (pain reduction in knee osteoarthritis), STEP-10 (reversion to normoglycaemia in pre-diabetic, obese patients), ESSENCE (resolution of MASH, improvement in fibrosis) Tirzepatide : SUMMIT (risk reduction in HFpEF outcomes

Tolerability and feasibility of at-home remotely supervised transcranial direct current stimulation (RS-tDCS): single-center evidence from 6,779 sessions

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The common problems are acute mountain sickness (AMS), insomnia, lack of appetite, tiredness, lethargy, upset stomach, disinclination to work, bone and muscle degradation, high-altitude pulmonary edema (HAPE), high-altitude cerebral edema (HACE), and all resulted in decrease in physical and mental performance in unacclimatized individuals [48]

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