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small variations in combined estimates in sensitivity and subgroup analysis

Here, they get monthly vitamin B12 injections

1 If vitamin B 12 deficiency coexists with folate deficiency, vitamin B 12 should be replaced first to prevent subacute combined degeneration of the spinal cord

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Inhibitors of NAD+ biosynthesis, particularly those targeting nicotinamide phosphoribosyltransferase (NAMPT), have shown potential in preclinical models, although resistance mechanisms such as alternative NAD+ biosynthetic pathways can limit their effectiveness

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