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This phenomenon speeds up aging and the development of age-related diseases

In addition, other conditions like folate deficiency, myelodysplastic syndromes (MDS), hypothyroidism, and chronic alcoholism can lead to macrocytic anemia and pancytopenia, making the diagnostic process more complex [7,8]

For patients without absorption disorders, high-dose oral supplements of 1,000 to 2,000 mcg daily have been shown to be comparably effective at correcting mild to moderate deficiency at lower cost and greater convenience.

Sanz-Cuesta et al., 2020

However, some patients experience side effects such as fatigue, nausea, and mild deficiencies in key nutrients due to reduced food intake