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indicated that GPX3 expression is downregulated in the lung tissues of IPF patients, leading to increased oxidative stress and exacerbating the fibrotic phenotype [126]
Therefore, the results highlight the critical role of oxidative balance in male fertility, where excessive reactive oxygen species can lead to cellular damage, particularly in sperm cells via Nrf2, which plays a key role in maintaining redox homeostasis by regulating antioxidant defense mechanisms, thereby protecting sperm quality

Ancajas CMF, Oyedele AS, Butt CM, Walker AS
Xu et al., 2016)

Wakamatsu, K

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