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via NF-B and mitochondria dependent pathways

Cancer Treat Rev 66:95-103, 2018

(2011) Acta Crystallogr Sect F Struct Biol Cryst Commun 67 : 1038-1043 PubMed: 21904047 Search on PubMedSearch on PubMed Central DOI: Primary Citation Related Structures: 3LG6, 3N5O PubMed Abstract: Coccidioides immitis is a pathogenic fungus populating the southwestern United States and is a causative agent of coccidioidomycosis, sometimes referred to as Valley Fever

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In apoptosis, -sitosterol upregulates pro-apoptotic factors such as p53 and Bax, while downregulating anti-apoptotic proteins such as Bcl-2, leading to an increase in mitochondrial outer membrane permeability and the activation of key apoptotic enzyme cascades such as caspase-9 and 3, which induces programmed cell death (83)