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Post-inflammatory hyperpigmentation (PIH): This occurs after trauma or inflammation, such as acne, leading to dark marks where the skin has healed

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Because TB-500 reaches all tissues rather than concentrating at one site, the dosing strategy focuses on sustaining a systemic therapeutic level across the cycle rather than targeting a precise anatomical location

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People are impatient and think a vigorous shake will speed things up

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This is especially important for patients with absorption issues such as those with digestive conditions, low stomach acid (common with aging), or MTHFR gene variants who cannot adequately absorb B12 from food or oral supplements

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Circulation 122:S729S767 Tang PT, Do DH, Li A, Boyle NG (2018) Team management of the ventricular tachycardia patient

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