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(2) Alternative Pathway for Certain Antimicrobial Products For applications received for new technology add-on payments for certain antimicrobial products, beginning with FY 2021, if a technology is designated by FDA as a QIDP and received FDA marketing authorization, and, beginning with FY 2022, if a drug is approved under FDA's LPAD pathway and used for the indication approved under the LPAD pathway, it will be considered not substantially similar to an existing technology for purposes of new technology add-on payments and will not need to meet the requirement that it represent an advance that substantially improves, relative to technologies previously available, the diagnosis or treatment of Medicare beneficiaries

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Four of the studies had data on D-dimer and oxygenation index (PaO 2 /FiO 2 ratio), and pooled analysis showed that NAC treatment significantly reduced D-dimer levels in patients with COVID-19 compared to the placebo group [SMD, 0.35, (95% CI: 0.59 to 0.10)

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