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PubMed, Mahato, Dipendra Kumar, et al
(2014) S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death, Cell Rep
SELENOW expression in the brain of mice has been found to confer protection against oxidative stress-induced neuronal cell death (21)
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Furthermore, in tumor cells where IGF-1R and INSR are co-expressed, upregulated INSR can compensate for IGF-1R inhibition, thereby limiting sustained inhibition of downstream signaling and contributing to resistance to IGF-1R-targeted therapy [25, 26]
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