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10.1146/annurev.pp.31.060180.002013 11 CabibboA.PaganiM.FabbriM.RocchiM.FarmeryM

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[7] The protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell death and increases resistance to toxic challenges, especially oxidative stress

Insulin resistance can disrupt glucose metabolism ( Figure 1 Diabetes is also caused by excessive reactive oxygen species (ROS) produced in obese people, which causes the proliferative arrest of pancreatic beta -cells (28, 29) (Figure 2)

The 25-year follow-up of this trial found that co-supplementation with these two micronutrients actually led to small increases in risk of death from gastric cardia cancer and cancer in general, but not death from esophageal cancer (54)

S2CID 2011527