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The study had, as its primary endpoint, changes in Unified Parkinsons Diseases Rating Scale (UPDRS), but despite that serum levels of CoQ 10 were increased in all patients in a way similar to the administration of 1200 mg/day performed by Shults et al., in 2002, no significant changes in UPDRS were observed, suggesting that in a mid-stage of PD, the CoQ 10 supplementation does not induce symptomatic effects [77]

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For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents: To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions

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[DOI] [PMC free article] [PubMed] [Google Scholar] 631.Zaidi N, Lupien L, Kuemmerle NB, Kinlaw WB, Swinnen JV, Smans K