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The Val66Met polymorphism data shows that Met carriers experience stronger overnight memory decay, suggesting that sleep-dependent BDNF processes are genetically modulated

Medicina (Kaunas) 2022;58

If you suspect degradation, replacing the medication is the safest path forward

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Gasperi C, Salmen A, Antony G, Bayas A, Heesen C, Kmpfel T, Linker RA, Paul F, Stangel M, Tackenberg B, Bergh FT, Warnke C, Weber F, Wiendl H, Wildemann B, Zettl UK, Ziemann U, Zipp F, Tumani H, Gold R, Hemmer B