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Interestingly, the low free carnitine group illustrated a seizure increase of 67.68% at the second timepoint (1 to 2 years) and is significantly different ( p = 0.0372) compared to the normal carnitine group, which showed a seizure reduction of 10.68%

Liver samples were obtained following isoflurane euthanasia by cervical dislocation, and their weights were recorded before storing them according to the requirements of different experimental protocols

This, in turn, has been shown to impair the Nrf2-Keap1-HO-1/NQO1 pathway, leading to the induction of autophagy-dependent ferroptosis and apoptosis of Purkinje cells

Over the past twenty years, there have been major improvements in the pharmacological treatment of RA