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Chimeric antigen receptor macrophages (CAR-Ms) may emerge as a breakthrough to overcome CAR-T limitations in solid tumors, leveraging their enhanced tumor infiltration capacity (NCT04660929) and potential metabolic advantages ( Tissue-resident macrophages exhibit high adaptability, integrating diverse TME signals to drive polarization toward immunosuppressive, pro-tumorigenic, and pro-metastatic functional states ( 5 Conclusions Glutamine plays a pivotal role in energy metabolism and the synthesis of biological macromolecules, underscoring its significance in tumor progression and immune responses

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