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In experimental research, the GHK-Cu complex has attracted interest due to its interactions with pathways involved in extracellular matrix regulation, cellular repair mechanisms, and gene expression associated with tissue maintenance

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Interactions have been studied between mercuric chloride, potassium dichromate, citrinin, and hexachloro-1,3-butadiene (HCBD) in vivo and in vitro using a rat model (Baggett & Berndt 1984a,b

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Overall, these studies highlight the role of adipocyte lipolysis in inter-organ crosstalk through the release of lipid signals and EVs to regulate whole body tissue homeostasis (Figure 4)