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As a result, cancer researchers emphasize identifying the biological processes that drive cancerous cells to migrate and potential strategies to inhibit metastasis (Zuazo-Gaztelu and Casanovas, 2018)

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The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed

Cell Stress and Chaperones 5, 276290