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In addition to the current mechanism of the effects of the MeDiet on the response to oxidation and inflammation, another candidate and potential neuroprotective mechanism might be associated with the roles mediated by this dietary pattern in regulating and/or protecting the gut microbiota composition of the gut-brain axis (7, 114)
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10.1016/j.cell.2023.03.010 84 KciukM.GieleciskaA.MujwarS.KoatD.Kauziska-Koat.CelikI.et al (2023)
Therefore, the uncertainty resulting from some prospective studies is partially resolved, because elevated circulating homocysteine is a major independent causative risk factor for cardiovascular disease

Traditionally, before any first in man clinical trials can be conducted, there is an extensive preclinical study trajectory
