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doi: 10.1152/physrev.00050.2017

In hair loss, the idea is that certain peptides may help the scalp environment or support hair follicle activity

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LY294002, a PI3K inhibitor, blocked PI3K/Akt signaling in osteoblasts and inhibited cell proliferation, ALP activity, calcium accumulation, and expression of osteogenic markers, indicating that the PI3K/Akt pathway is essential for osteoblast function and mineralized bone formation is critical (Zhou et al., 2019)

There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)

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