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First, mRNAs of NRF2, as well as of Heme Oxigenase 1 (HO-1) and GCL, two enzymes whose expression is known to be under the control of NRF2, were quantified by qRT-PCR (Figure 5A)

NOX-derived ROS stimulate the transcription of pro-inflammatory genes via factors such as NF-B (9092) or NFAT (93)

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Recent advancements in nanodelivery systems, such as microneedle-assisted nanostructured lipid carriers, have enhanced localized drug delivery, showing significant inhibition of MDA-MB-231 cell migration and tumor growth in xenograft models [30]

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