glutathione thioesters Biocompatibility and Physiological Thiolytic Degradability of Radically Made Thioester-Functional Copolymers: Opportunities for Drug Release Supports formation of the key antioxidant compound glutathione. Glutathione Metabolism - an overview
Description
doi:10.1038/s41598-022-13816-8 40
Free Radic Res 2007
47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG
Research has found that the gel formulations of GA were commonly used in cosmetics, reducing lipid peroxidation by 33.97%, which confirmed their antioxidant effects in the skins stratum corneum (Monteiro E Silva et al., 2017)
However, further studies are still needed to optimize its clinical application, including dosage form improvement, combination therapy strategies and long-term safety assessment
Our previous study showed that H 2 S and NO 2 treatment upregulated the relative expression of CYP2R1 and CYP27B1 genes in THP-1 monocytes [151]
