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Importantly, as only unbound drugs can interact with the target in the brain, increased nonspecific brain tissue binding can affect unbound drug concentrations in the brain

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doi: 10.3892/etm.2019.7350 83 ChaithongyotSJantareePSokolovaONaumannM
(2006) The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress
The healing process can be slow and fraught with setbacks, requiring a long-term commitment to consistent care and treatment

FM: Conceptualization, Funding acquisition, Supervision, Writing original draft, Writing review & editing