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To synthesize the dimeric macrocycles, a 22-mM solution of the respective C-terminal cysteine-modified monomer peptide in DMSO was incubated with 10 mM of the bis-maleimide linker in 50 mM Hepes-HCl (pH 7.5) with 90% (v/v) DMSO

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However, there are also cases when additional factors such as lack of sleep, poor diet, and deficiency of other vitamins like iron, folate, and others, contribute to the issue

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Significantly stronger fluorescence was observed in the lungs of LyP-1-injected BLM mice than in all the other groups at 2 h after FITC-labeled peptide injection, indicating the binding of LyP-1-FITC to the lungs of BLM mice (Fig