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ROS such as hydrogen peroxide serve as signaling molecules, stimulating the action of vasoactive agents like Ang II, ET-1, aldosterone, and prostanoids, while also influencing calcium homeostasis [63]

It was thought that iron in liver tissue, not liver juice-soluble factor, cured hemorrhagic anemia in dogs

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In addition, other hormones such as glucagon, adiponectin, and growth hormone also contribute to thyroid regulation, although their role in KD is less well defined

TFRC permits access to ferritin-bound iron for cellular use (ferritinophagy), in a process that allows iron release from ferritin and conversion of ferric iron (Fe 3+ ) to bioactive ferrous iron (Fe 2+ )