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391 This study also showed that serum levels of ICAM-1, IL-1, IL-6, IL-18, MDA, vascular cell adhesion molecule 1 (VCAM-1), and transcript levels of Bcl-2 associated X (Bax) and TLR-4 were reduced, and levels of catalase, IL-10, SOD, TAC, Bcl-2, and Nrf-2 were increased in patients treated with nanocurcumin versus the placebo

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Future research should adopt a targeted approach that prioritizes clinical translation