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MPTP and Parkinson MPTP is a widely used neurotoxicant, known for the induction of Parkinson-like symptoms such as bradikinesia, movement disorders, -synuclein bodies, mitochondrial abnormalities, sustained inflammation in the substantia nigra and activation of the microglia [6,10,15, 79-80]

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Notably, the concentration of e-CAT in humans was higher than in other mammalian species, exceeding five to six times the levels in goat and sheep

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The activity reverts to the original level within 23 days if the agent is withdrawn