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Primary Handling Editor: Sonia Muliyil, in collaboration with the Nature Medicine team

Medications frequently interfere with B12 status

UK treatment for severe deficiency involves hydroxocobalamin 1mg intramuscular injections, with regimens varying based on neurological involvement

Long-term deficiency can damage the protective myelin around nerves, and if it is not addressed, some of that damage can become permanent, causing numbness, pain, and balance problems

Hormone disruption: It doesn't affect testosterone, estrogen, thyroid, or other hormones

Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease