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10.1016/s0021-9258(17)36700-5 2 AlbertiK

In vivo , Hong et al

Parenteral B12 use: Deficiency of B12 causes megaloblastic anemia and neurological symptoms (fatigue, tingling, memory problems)

Importantly, animals were singly housed to eliminate the exchange and cross-contamination of intestinal microbiomes, a factor that potentially biases studies with group-housed animals by minimizing microbiome variations for co-housed animals within a cohort

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Methionine and choline are generally more stable but can still be affected by prolonged heat exposure