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Metabolic inhibition may exacerbate the systemic toxicity of cytotoxic drugs by weakening the stress tolerance of normal proliferative tissues

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[19] Although female carriers can have a mild form of G6PD deficiency (dependent on the degree of inactivation of the unaffected X chromosome see Skewed X-inactivation ), homozygous females have been described

The clinician also recorded any signs of patient discomfort or inability to talk
