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32 Other studies have reported hyperammonaemia in 50% and 29/55 (53%) of patients receiving VPA

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The resultant dehydration can induce dizziness, weakness, muscle cramps, and lead to potentially dangerous organ problems

Changes in the pentose phosphate pathway in HF The regulation of the cellular redox environment is tightly linked to substrate metabolism via the PPP as an important source of NADPH

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Current treatments primarily focus on symptom management, with limited efficacy in halting or reversing disease progression