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2.5 Quality assessment and risk of bias In line with PRISMA guidelines, the assessment of methodological quality was conducted to evaluate the strength of evidence, recognising that methodological limitations may introduce bias

For severe cases, the first dose is usually 1,000 mcg given intramuscularly every day or every other day for a week or two

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Clinical Interpretation Several aspects of these results deserve expert-level analysis: The biphasic dose-response is clinically important

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Methylcobalamin products are typically available as food supplements rather than licensed medicines
