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Description
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Secondary mitochondrial disorders are considered those that involve mitochondrial dysfunction that arises from factors besides directly impaired oxidative phosphorylation, such as pathogenic variants in mitochondrial-related resilience mechanisms, disease-specific pathological events (e.g., protein aggregation), oxidative stress, or exposure to harmful external agents, often manifesting in broader systemic clinical phenotypes [128]

Depletion of the endogenous antioxidants including GPx can overwhelm antioxidant defence mechanisms, resulting in oxidative stress medicated vitiligo

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Barrio-Cortes J

doi: 10.1016/j.jacc.2012.08.997
