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Across models spanning tendons, ligaments, muscle, bone and the GI (gastrointestinal) tract, the same core mechanisms appear repeatedly, which is either a sign of genuine pleiotropic biology or publication bias

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One possibility is that the changes in the excitatory and inhibitory synapse number/function, as indicated by mEPSC and mIPSC assessment, represent compensatory mechanisms to maintain normal action potential and multivesicular release mediated neurotransmission

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( Summary Glutathione biosynthesis plays a key role in maintaining redox balance and homeostasis in plants

Methods/design The proposed study involves a controlled, randomised, multicentre, parallel, non-inferiority clinical trial lasting one year, involving 23 primary healthcare centres in the Madrid region (Spain), and patients 65 years of age