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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury (Fang et al., 2025)

DOI: 10.1016/j.ultsonch.2009.10.015 48

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However, other studies have reported mixed results, with some trials showing no significant impact on TB relapse or culture conversion [77, 78]