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This is because the efficacy of a countercurrent system decreases when transit time decreases, as would occur if medulla BF increases

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Due to the strong affinity of hyaluronic acid (HA) for the CD44 receptor, MDA-MB-231Br (a kind of metastatic breast cancer cell) may take up an ultra-small (~5 kDa) HA-PTX nanoconjugate through CD44 receptor-mediated endocytosis (142)

Natl Res Cent 44:112

D., Banerjee, S., Stolarczyk, E