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Thyroid follicular cells in HT patients can aberrantly express both B7.1 and MHC class II molecules, enabling them to function as non-professional APCs and directly participate in autoimmune activation

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Specifically, a few amino acids in the Perfect Amino formula stand out as the main culprits of this fast-breaking potential: valine, methionine, histidine, leucine, and isoleucine

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However, treatment with Mn@mHSA or P-Mn@mHSA attenuated the secretion of TNF- and IL-6, with cells treated with P-Mn/TI@mHSA exhibiting the lowest concentrations of these cytokines due to synergistic effects